解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Pheochromocytomas (PCCs) are tumors arising from neural crest-derived chromaffin cells. There are currently few animal models of PCC that recapitulate the key features of human tumors. Because such models may be useful for investigations of molecular pathomechanisms and development of novel therapeutic interventions, ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1108
更新日期:2016-08-01 00:00:00
abstract::Exercise has a potent insulin-sensitivity enhancing effect on skeletal muscle, but the intracellular mechanisms that mediate this effect are not well understood. In muscle, Ras-related C3 botulinum toxin substrate 1 (Rac1) regulates both insulin- and contraction-stimulated glucose transport and is dysregulated in insu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1220
更新日期:2016-08-01 00:00:00
abstract::Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups we...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1239
更新日期:2016-08-01 00:00:00
abstract::Neutrophils are important effector cells of the innate immune system. Thyroid hormone (TH) is thought to play an important role in their function. Intracellular TH levels are regulated by the deiodinating enzymes. The TH-inactivating type 3 deiodinase (D3) is expressed in infiltrating murine neutrophils, and D3 knocko...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1103
更新日期:2016-08-01 00:00:00
abstract::Nowadays, we are bombarded with information on a large number of endocrine-disrupting chemicals. We hear and read about endocrine-disrupting chemicals on blogs, the web, news stories, television specials, advertisements, and of course scientific articles. Reports claim these ubiquitous compounds are responsible for in...
journal_title:Endocrinology
pub_type: 历史文章,杂志文章
doi:10.1210/en.2016-1445
更新日期:2016-08-01 00:00:00
abstract::GnRH neurons are regulated by hypothalamic kisspeptin neurons. Recently, galanin was identified in a subpopulation of kisspeptin neurons. Although the literature thoroughly describes kisspeptin activation of GnRH neurons, little is known about the effects of galanin on GnRH neurons. This study investigated whether gal...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1064
更新日期:2016-08-01 00:00:00
abstract::The power of animal models is derived from the ability to control experimental variables so that observed effects may be unequivocally attributed to the factor that was changed. One variable that is difficult to control in animal experiments is the number and composition of offspring in a litter. To account for this v...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2016-1145
更新日期:2016-07-01 00:00:00
abstract::Thyroid hormones play a major role in body homeostasis, regulating energy expenditure and cardiovascular function. Given that obese people or athletes might consider rapid weight loss as beneficial, voluntary intoxication with T4 preparations is a growing cause for thyrotoxicosis. However, the long-lasting effects of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1095
更新日期:2016-07-01 00:00:00
abstract::Kisspeptin-neurokinin B-dynorphin (KNDy) cells of the hypothalamus are a key component in the neuroendocrine regulation of GnRH secretion. Evidence in sheep and other species suggests that dynorphin released by KNDy cells inhibits pulsatile GnRH secretion by acting upon κ-opioid receptors (KOR). However, the precise a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1763
更新日期:2016-06-01 00:00:00
abstract::Des-acyl ghrelin (DAG), the most abundant form of ghrelin in humans, has been found to reduce arterial blood pressure and prevent cardiac and endothelial cell apoptosis. Despite this, data regarding its direct effect on cardiac function and coronary blood flow, as well as the related involvement of autonomic nervous s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1922
更新日期:2016-06-01 00:00:00
abstract::Iodine deficiency (ID) induces TSH-independent microvascular activation in the thyroid via the reactive oxygen species/nitric oxide-hypoxia-inducible factor-1α/vascular endothelial growth factor (VEGF) pathway. We hypothesized the additional involvement of mammalian target of rapamycin (mTOR) as a positive regulator o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1911
更新日期:2016-06-01 00:00:00
abstract::The possibility that chronic, multigenerational exposure to environmental estrogens selects for adaptive hormone-response phenotypes is a critical unanswered question. Embryos/larvae of killifish from an estrogenic-polluted environment (New Bedford Harbor, MA [NBH]) compared with those from a reference site overexpres...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1052
更新日期:2016-06-01 00:00:00
abstract::Rat sexual maturation is preceded by a reduction of the interpulse interval (IPI) of GnRH neurosecretion. This work aims at studying disruption of that neuroendocrine event in females after early exposure to a very low dose of bisphenol A (BPA), a ubiquitous endocrine disrupting chemical. Female rats were exposed to v...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1937
更新日期:2016-05-01 00:00:00
abstract::The first mutation in a gene associated with a neuronal migration disorder was identified in patients with Kallmann Syndrome, characterized by hypogonadotropic hypogonadism and anosmia. This pathophysiological association results from a defect in the development of the GnRH and the olfactory system. A recent genetic s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1846
更新日期:2016-05-01 00:00:00
abstract::We recently described a preclinical model of Graves' orbitopathy (GO), induced by genetic immunization of eukaryotic expression plasmid encoding human TSH receptor (TSHR) A-subunit by muscle electroporation in female BALB/c mice. The onset of orbital pathology is characterized by muscle inflammation, adipogenesis, and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1829
更新日期:2016-04-01 00:00:00
abstract::Thyroid hormones (THs) are charged and iodinated amino acid derivatives that need to pass the cell membrane facilitated by thyroid hormone transmembrane transporters (THTT) to exert their biological function. The importance of functional THTT is affirmed by the devastating effects of mutations in the human monocarboxy...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1933
更新日期:2016-04-01 00:00:00
abstract::Agouti-related protein (AgRP) expressed in the arcuate nucleus is a potent orexigenic neuropeptide, which increases food intake and reduces energy expenditure resulting in increases in body weight (BW). Glucocorticoids, key hormones that regulate energy balance, have been shown in rodents to regulate the expression of...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1430
更新日期:2016-04-01 00:00:00
abstract::Hypothyroidism is the most frequent and earliest endocrine complication in cystinosis, a multisystemic lysosomal storage disease caused by defective transmembrane cystine transporter, cystinosin (CTNS gene). We recently demonstrated in Ctns(-/-) mice that altered thyroglobulin biosynthesis associated with endoplasmic ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1762
更新日期:2016-04-01 00:00:00
abstract::Mouse β-cell-specific reporter lines have played a key role in diabetes research. Although the rat provides several advantages, its use has lagged behind the mouse due to the relative paucity of genetic models. In this report we describe the generation and characterization of transgenic rats expressing a Renilla lucif...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1550
更新日期:2016-03-01 00:00:00
abstract::The most significant increase in metabolic syndrome over the previous decade occurred in women of reproductive age, which is alarming given that metabolic syndrome is associated with reproductive problems including subfertility and early pregnancy loss. Individuals with metabolic syndrome often consume excess fructose...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1618
更新日期:2016-02-01 00:00:00
abstract::CD36/FAT (fatty acid translocase) is associated with human and murine nonalcoholic fatty liver disease, but it has been unclear whether it is simply a marker or whether it directly contributes to disease pathogenesis. Mice with hepatocyte-specific deletion of Janus kinase 2 (JAK2L mice) have increased circulating free...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1866
更新日期:2016-02-01 00:00:00
abstract::The neuropeptide kisspeptin (Kiss1) is integral to the advent of puberty and the generation of cyclical LH surges. Although many complex actions of Kiss1 are known, the mechanisms governing the processing/regulation of this peptide have not been unveiled. The metallo enzyme, endopeptidase 24.15 (thimet oligopeptidase)...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1580
更新日期:2016-02-01 00:00:00
abstract::Clinical studies indicate alternate-day, intermittent fasting (IMF) protocols result in meaningful weight loss in obese individuals. To further understand the mechanisms sustaining weight loss by IMF, we investigated the metabolic and neural alterations of IMF in obese mice. Male C57/BL6 mice were fed a high-fat diet ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1622
更新日期:2016-02-01 00:00:00
abstract::Type 1 diabetes is caused by autoimmune destruction of β-cells. Although immunotherapy can restore self-tolerance thereby halting continued immune-mediated β-cell loss, residual β-cell mass and function is often insufficient for normoglycemia. Using a growth factor to boost β-cell mass can potentially overcome this ba...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1549
更新日期:2016-01-01 00:00:00
abstract::The hypoxic growth plate cartilage requires hypoxia-inducible factor (HIF)-mediated pathways to maintain chondrocyte survival and differentiation. HIF proteins are tightly regulated by prolyl hydroxylase domain-containing protein 2 (Phd2)-mediated proteosomal degradation. We conditionally disrupted the Phd2 gene in ch...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1473
更新日期:2016-01-01 00:00:00
abstract::Embryonic poly(A)-binding protein (EPAB) is the predominant poly(A)-binding protein in Xenopus, mouse, and human oocytes and early embryos before zygotic genome activation. EPAB is required for translational activation of maternally stored mRNAs in the oocyte and Epab(-/-) female mice are infertile due to impaired ooc...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1135
更新日期:2016-01-01 00:00:00
abstract::Hyperandrogenism is the central feature of polycystic ovary syndrome (PCOS). Due to the intricate relationship between hyperandrogenism and insulin resistance in PCOS, 50%-70% of these patients also present with hyperinsulinemia. Metformin, an insulin sensitizer, has been used to reduce insulin resistance and improve ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1733
更新日期:2016-01-01 00:00:00
abstract::Monocarboxylate transporter 8 (MCT8) is a thyroid hormone transmembrane transporter expressed in many cell types, including neurons. Mutations that inactivate transport activity of MCT8 cause severe X-linked psychomotor retardation in male patients, a syndrome originally described as the Allan-Herndon-Dudley syndrome....
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1393
更新日期:2015-12-01 00:00:00
abstract::Humanin is a peptide that is cytoprotective against stresses in many cell types. We investigated whether a potent humanin analogue S14G-humanin (HNG) would protect against chemotherapy-induced damage to normal cells without interfering with the chemotherapy-induced suppression of cancer cells. Young adult male mice we...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1542
更新日期:2015-12-01 00:00:00
abstract::Recently, California condors (Gymnogyps californianus) have been reintroduced to coastal regions of California where they feed on marine mammal carcasses. There is evidence that coastal-dwelling condors experience reproductive issues, such as eggshell thinning, likely resulting from exposure to endocrine-disrupting ch...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1448
更新日期:2015-12-01 00:00:00
abstract::Estrogen deficiency causes bone loss by increasing the number of bone-resorbing osteoclasts. Selective p38α MAPK inhibitors prevent bone-wasting effects of estrogen withdrawal but implicated mechanisms remain to be identified. Here, we show that inactivation of the p38α-encoding gene in osteoblast lineage cells with t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1669
更新日期:2015-12-01 00:00:00
abstract::A relationship between the actions of TSH and IGF-1 was first recognized several decades ago. The close physical and functional associations between their respective receptors (TSHR and IGF-1R) has been described more recently in thyroid epithelium and human orbital fibroblasts as has the noncanonical behavior of IGF-...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1464
更新日期:2015-12-01 00:00:00
abstract::Maintenance of cell polarity is essential for Sertoli cell and blood-testis barrier (BTB) function and spermatogenesis; however, the signaling mechanisms that regulate the integrity of the cytoskeleton and polarity of Sertoli cells are not fully understood. Here, we demonstrate that rapamycin-insensitive component of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1217
更新日期:2015-11-01 00:00:00
abstract::Metastatic pheochromocytoma continues to be an incurable disease, and treatment with conventional cytotoxic chemotherapy offers limited efficacy. In the present study, we evaluated a novel topoisomerase I inhibitor, LMP-400, as a potential treatment for this devastating disease. We found a high expression of topoisome...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1476
更新日期:2015-11-01 00:00:00
abstract::Xenoestrogens from synthetic or natural origin represent an increasing risk of disrupted endocrine functions including the physiological activity of the hypothalamo-pituitary-gonad axis. Ethinyl estradiol (EE2) is a synthetic estrogen used in contraceptive pills, whereas zearalenone (ZEA) is a natural mycoestrogen fou...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1330
更新日期:2015-11-01 00:00:00
abstract::Remodeling of maternal spiral arteries during pregnancy requires a subpopulation of extravillous cytotrophoblasts (EVTs) to differentiate into endovascular EVTs. Activin A, which is abundantly expressed at the maternal-fetal interface, has been shown to promote trophoblast invasion, but its role in endovascular differ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1228
更新日期:2015-11-01 00:00:00
abstract::We recently reported that chronic 17β-estradiol (E2) treatment in mice decreases platelet responsiveness, prolongs the tail-bleeding time and protects against acute thromboembolism via the hematopoietic estrogen receptor alpha (ERα), and independently of ERβ. Here, we have explored the respective roles of membrane vs ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1522
更新日期:2015-11-01 00:00:00
abstract::Obesity is associated with systemic inflammation and elevated levels of TNFα, leading to impaired glucose tolerance. In humans, obesity is also associated with reduced nutrient-stimulated secretion of the intestinal incretin hormone, glucagon-like peptide-1 (GLP-1). We hypothesized that TNFα plays a direct role in the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1361
更新日期:2015-11-01 00:00:00
abstract::Loss of circulating 17β-estradiol (E2) that occurs during menopause can have detrimental effects on cognitive function. The efficacy of hormone replacement therapy declines as women become farther removed from the menopausal transition, yet the molecular mechanisms underlying this age-related switch in E2 efficacy are...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1514
更新日期:2015-11-01 00:00:00
abstract::Due to increased numbers of young cancer patients and improved survival, the impact of anticancer treatments on fertility has become a major health concern. Despite mounting research on ovarian toxicity, there is paucity of data regarding reliable biomarkers of testicular toxicity. Our aim was to evaluate anti-Mülleri...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1310
更新日期:2015-10-01 00:00:00